Middle of the Road Recommendations

I do a pretty good job of keeping up with what's new in "art comics" - Fantagraphics, Picturebox, D&Q, etc. And I keep up as much as I want to with what's new in Big Two super-hero comics. What I'm more or less clueless about are non-Big Two genre books: the contemporary equivalent of Matt Wagner's Grendel stories, Nexus, Zot!, etc. Any suggestions of good/interesting stuff to look out for? I'm especially interested in recommendations of these type of comics written/drawn by guys who don't have a Big Two presence (i.e., not Robert Kirkman, Warren Ellis, or Ed Brubaker).